methylCC: technology-independent estimation of cell type composition using differentially methylated regions
Abstract Karaoke CDs A major challenge in the analysis of DNA methylation (DNAm) data is variability introduced from intra-sample cellular heterogeneity, such as whole blood which is a convolution of DNAm profiles across a unique cell type.When this source of variability is confounded with an outcome of interest, if unaccounted for, false positives